LIU Xueni, ZHANG Yiqun, CHEN Feng, WU Mei, ZHANG Yuanyuan, ZHAO Guifeng. Association between sudden onset in confined spaces and disease severity and short-term clinical outcomes in patients with aneurysmal subarachnoid hemorrhage[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2023, 44(3): 234-238. DOI: 10.3969/j.issn.2095-5227.2023.03.006
Citation: LIU Xueni, ZHANG Yiqun, CHEN Feng, WU Mei, ZHANG Yuanyuan, ZHAO Guifeng. Association between sudden onset in confined spaces and disease severity and short-term clinical outcomes in patients with aneurysmal subarachnoid hemorrhage[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2023, 44(3): 234-238. DOI: 10.3969/j.issn.2095-5227.2023.03.006

Association between sudden onset in confined spaces and disease severity and short-term clinical outcomes in patients with aneurysmal subarachnoid hemorrhage

  •   Background  Aneurysmal subarachnoid hemorrhage (aSAH) is a common cerebrovascular disease with high mortality and morbidity rates. Confined spaces are often small, with low oxygen levels and poor ventilation. It has been found that many aSAH patients have sudden onset in confined spaces. The association between onset in confined spaces and disease severity and prognosis in aSAH patients remains unclear.
      Objective  To investigate the association between sudden onset in confined spaces and disease severity as well as short-term clinical outcomes in aSAH patients.
      Methods  Clinical data about patients with aSAH admitted to the PLA Rocket Force Characteristic Medical Center from January 2014 to December 2020 were retrospectively analyzed. The severity of the disease was assessed using the Hunt-Hess scale, and clinical outcome was evaluated using the Glasgow Outcome Scale (GOS). The patients were divided into groups according to disease severity and short-term clinical outcomes, and differences between the two groups were analyzed. Binary multivariate logistic regression was performed to analyze whether the confined space was a predictor of disease severity and short-term prognosis in aSAH patients.
      Results  A total of 30 aSAH patients had sudden onset in confined spaces and 96 patients in open spaces, and there were no significant differences in sex (male/female: 12/18 vs 38/58) and age (59.0±15.4 years vs 58.3±14.0 years) between the two groups (P>0.05). The proportion of aSAH patients with more severe disease and poor prognosis were significantly higher in the confined space group 9(30.0) vs 8(8.3), P=0.006; 17(56.7) vs 23(24.0), P=0.001. Multivariable logistic regression analysis showed that aSAH onset in confined spaces was an independent risk factor for short-term clinical outcome (OR=4.213, 95% CI: 1.554-11.421, P=0.005), but it was not an independent risk factor for disease severity in aSAH patients (OR=3.153, 95% CI: 0.933-10.653, P=0.064).
      Conclusion  The onset of aSAH in confined spaces is independently associated with the short-term clinical outcomes but not with the disease severity of aSAH patients.
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