Change of serum C-reactive protein and urine microalbumin in patients with type 2 diabetes mellitus complicated by metabolic syndrome and its relation with angiopathy

Objective To study the change of serum C-reactive protein（CRP） and urine microalbumin（Alb/Cr） levels in patients with type 2 diabetic mellitus complicated by metabolic syndrome（MS） and to evaluate its related macrovasculopathy. Methods One hundred and thirty-two patients with type 2 diabetes mellitus were divided into MS group and non-MS group.MS group was divided into 4 subgroups.Serum CRP and urine Alb/Cr levels were measured by enzymatic linked immunosorbent assay（ELISA） and with DCA2000,respectively. Results The serum CRP and urine Alb/Cr levels were significantly higher in patients with diabetic mellitus complicated by MS than in those not complicated by MS and normal controlsCRP:2.49（1.14-8.78）,1.57（0.18-4.00）,0.37（0.171.18）mg/L,P＜0.01;Alb/Cr:28.0（10.00-118）,8.5（5.0-14）,4.10（2.02-5.71）mg/g,P＜0.01.The serum CRP and urine Alb/Cr levels increased gradually with the increased clustering of MS components.The incidence of macrovasculopathy in patients complicated by MS was obviously higher（39.4%）than in those not complicated by MS（28.3%）（P＜0.05）.The incidence of macrovasculopathy in the 4 subgroups was 12.5%,35.1%,47.2%,and 51.2%,respectively.The CRP concentration was positively correlated with urine Alb/Cr and accumulated MS components（r=0.217,P=0.05;r=0.220,P=0.012）.Spearman correlation analysis showed that the CRP level was positively correlated with urine Alb/Cr（r=0.211,P=0.042）,BMI（r=0.215,P=0.033）,LDL-C（r=0.212,P=0.037） and HbA1c（r=0.333,P=0.001）. Conclusion Measurement of CRP and urine Alb/Cr levels in patients with type 2 diabetes mellitus complicated by MS contributes to the early discovery of MS and in those at a high risk of developing related vasculopathy.