Relationship between the gastric cancer and the expression of MUC1、MUC2 and MUC5AC in serum

Objective:To study the relationship between the gastric cancer and the expression of MUC1、 MUC2 and MUC5AC in serum.Methods: Mucins' protein chip was established and applied to measure the serum levels of MUC1,MUC2 and MUC5AC in 30 gastric cancer patients and 30 healthy adults as control,using the method of immuno-fluorescence.Results: The serum mucins and CEA levels of gastric cancer patients were significantly higher than that of the healthy ones（P＜0.01）.The positive expression of the MUC1was related with the gastric cancer's TNM stage（P＜0.01）,The positive expression of the MUC2 and MUC5AC had not relationship with the gastric cancer's stage（P＞0.05）.The positive expression of the mucins was related with the gastric cancer's differentiation.The sensibility and specificity were both higher in mucins when used to diagnose.The sensibility and specificity of MUC1 were 81.5%、 75.8% respectively.The sensibility and specificity of combined mucins（at least 2 in 3 mucins were positive） were 96.0%、 82.9%.Conclusion: To measure the serum levels of MUC1,MUC2 and MUC5AC could promote the sensibility and specificity in the diagnosis of gastric cancer and provide a new approach to early diagnose gastric cancer.