Efficiency of CCI models made with chromic gut and silk thread

Objective To compare the dynamic changes of pain threshold in CCI pain models made with chromic gut and silk thread. Methods Thirty healthy male SD rats were randomly divided into silk thread group,chromic gut group and sham-operation group（n=10）.The right sciatic nerves in rats of chromic gut and silk thread groups were ligated with chromic gut and silk thread,respectively.The right sciatic nerves in rats of sham-operation group were exposed without ligation.The thermal withdrawal threshold（TWT） and mechanical withdrawal threshold（MWT） were detected after the model was established. Results The pain threshold was lower in silk thread and chromic gut groups than in sham-operation group（P＜0.05） with no difference in MWT.However,the TWT was lower in chromic gut group than in silk thread group（P＜0.05）. Conclusion CCI model made with chromic gut can decrease the therma1 pain threshold more significantly than that made with silk thread.