Effects of thymosin α₁ on thrombocytopenia resulting from severe infection in the patients from ICU

Objective: To investigate the effect of Zadaxin（thymosin α1,Tα1） on thrombocytopenia induced by severe infection in the patients from ICU.Methods: Twenty ICU patients with severe infection were assigned to 2 groups: Group A（n=10） treated with general therapy,Group B（n=10） treated with not only general but also Zadaxin therapy.The blood routine was monitored before and during therapy,and the symptoms,signs as well as chest X-rays were also observed for all patients,and based on which,the curative effect would be evaluated for every patient.Results: （1） Before treatment,thrombocytopenia occurred to all patients,WBC and NEUT were in abnormally higher levels.（2） With the treatment,the levels of WBC（P＜0.05） and NEUT（P＜0.01） in the patients of Group B restored more markedly than those in the patients of Group A,and the level of PLT also restored more quickly in Group B than that in Group A（P＜0.05）.（3） The total curative rate for infection was 90% in Group B higher than that in Group A with the total curative rate of 70% with no statistical significance between the two groups（P＞0.05）.Conclusions: Zadaxin combined with other medicine therapy could promote the correction of the thrombocytopenia of the patients with severe infection,which would be beneficial to effectively control the severe infection of the patients from ICU.