Influence of blood pressure on free redical damage during cerebral ischemia and reperfusion in rabbits

The contents of Malondialdehyde（MDA） and Superoxide dismutase （SOD） were measured in the brain and blood of 45 rabbits. The epileptic seizures and pathological changes were observed to study the relationship between different levels of blood pressure and the generation of free radicals and their influence to brain damage during reperfusion. Results showed that the post-ischemic damage of brain became worse and free radicals’ generation most markedly increased in moderately and extremely hyper-tensive groups, less markedly in hypotensive group, but least seriously in normo-tensive group. It is coacluded that the blood pressure should be regulated to normal level （90-130mmHg） during precedure of reperfusion after the cerebral ischemia improves, to reduce the generation of free radicals and alleviate the brain damage.