Bacterial distribution and the surveillance of its resistance to antimicrobial agents

Objective: To understand bacterial distribution and resistance trend of inpatints and outpatients in our hospital Methods: The kind distribution and antimicrobial susceptibility of bacteria isolated from 1995 to 1999 were analysed by WHONET5 software Results: Pseudomonas aeruginosa,Escherichia coli and coagulase negative Staphylococcus were the three major infectious pathogens in our hospital Their resistance to most antimicrobial agents increased obviously with the year Specially,resistance of E coli to ciprofloxacin,piperacillin and trimethoprim/selfamethoxazole was 74.7%,81 1% and 81.5 respectively Resistance of P aeruginosa to cefoperazone,ciprofloxacin,gentamicin,amikacin and imipenem increased from 23.7%,9.3%,21.1%,6.8% and 6.3% in 1995 to 65%,31.3%,52.3%,23 4% and 18.4% in 1999 respectively Some bacteria possessed high and multiple antimicrobial agent resistance at one time MRSA reduced from 43.2% in 1995 to 19.4% in 1999,but oxacillin resistence coagulase negative Staphylococcus increased from 67.3% in 1995 to 74.2% in 1999 The isolated ratio of ESBL producing E coli and K pneumoniae was separately 13% and 16% in 1999 High level aminoglycoside resistant Enterococcus faecalis and Enterococcus faecium were 47 6% and 61 1% Conclusion: Resistance of the bacteria to antimicrobial agents was shown increasing trend in our hospital Clinical physician ought to understand the characteristics of bacterial resistance to antibitics in individual hospital,correctly and efficiently select antimicrobial agents Microbiology laboratory and clinical departments should have close cooperation to control the development of bacterial resistance