Abstract: Moderate to severe intrauterine adhesion (IUA) have great adverse effects on female reproductive health. The high adhesion recurrence rate, low pregnancy rate and unsatisfactory pregnancy outcome after hysteroscopic adhesiolysis have brought great challenges in clinical practice. Autologous platelet-rich plasma (PRP) contains high concentration of platelets, which is a rich source of bioactive factors such as growth factors and cytokines. These factors can promote cell proliferation, migration, regeneration, extracellular matrix remodeling, angiogenesis and epithelialization. Although PRP has been widely used in medicine for decades, its application in the treatment of IUA is still in the preliminary explore stage, and its exact mechanism remains unclear. This article reviews the research progress of PRP in the treatment of IUA, and focuses on its possible mechanism, in order to provide theoretical evidences for improving the therapeutic effect of IUA.