Abstract:
Background Intestinal bacterial overgrowth (SIBO) is the pathological growth of the gut microbiota of the small intestine. Recent studies have shown that hypercholesterolemia is associated with alterations in gut microbiota. However, the association between hypercholesterolemia and SIBO is poorly understood.
Objective To investigate the association between hypercholesterolemia and SIBO in middle-aged and elderly men.
Methods Male patients aged ≥50 years old who visited the Outpatient Department of Gastroenterology of the Second Medical Center of Chinese PLA General Hospital from October 2018 to October 2019 were enrolled. Subjects were divided into the SIBO (+) and SIBO (-) groups. Multivariate binary logistic regression model was used to evaluate the association between hypercholesterolemia and SIBO.
Results A total of 237 subjects were enrolled, including 50 subjects with hypercholesterolemia (prevalence 21.1%) and 166 subjects with SIBO (prevalence 70.04%). The proportion of hypercholesterolemia and history of gastroenterectomy in SIBO (+) group was higher than that in SIBO (-) group (P＜0.05). Multivariate logistic regression showed that after adjusting for age, BMI, history of gastrointestinal surgery, and serum levels of albumin, total protein and glutamyl transpeptidase, the incidence of SIBO in patients with hypercholesterolemia was 2.397 times of that in those with normal cholesterol (95% CI: 1.034-5.558).
Conclusion Hypercholesterolemia is positively associated with SIBO in middle-aged and elderly men with non-organic gastrointestinal disease in the outpatient department of gastroenterology.
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