Abstract: The incidence of endometrial cancer is increasing year by year, and its burden continues to increase. Conventional treatment for early high-risk, locally advanced, and metastatic endometrial cancers shows poor benefits. With the diversified development of detection technology and treatment mode exploration, tumor immunotherapy, as an important part of precision medicine, has gradually attracted much attention and been explored in the field of gynecological oncology after clinical demonstration of multiple tumor species. This paper reviews the progresses of tumor immunotherapy in combination with the development of molecular pathology. Meanwhile, the survival benefit data of patients with single immunotherapy and multiple novel immunotherapy regimens are analyzed, and the clinical application and prospect of immunotherapy for endometrial cancer are summarized, which is helpful for gynecologists to better understand the advantages and limitations of immunotherapy, carefully select the time, order, type and dose of combination medication, focus on the inflection point of clinical efficacy, and develop optimal strategies with clinical benefits.