Abstract: Bone tissue engineering (BTE) has a wide range of applications in bone repair as it provides the scaffold to match the defect in the early stage of the treatment of bone defects, guiding the ingrowth of new tissues and providing active factors and cells to promote bone regeneration. A good design of bone tissue engineering is crucial. Inspired by the properties of natural bone, the connection between BTE and bionic science is getting closer and closer, making biomimetics of composition, structure and function an attractive method for the preparation of BTE. Based on the properties of natural bone, different bionic approaches, such as compositional bionic, structural bionic and functional bionic, are briefly introduced, and their applications in BTE are reviewed, intending to provide new thoughts and methods for the design of BTE.