Abstract: Atherosclerosis (AS) is the main underlying pathology of ischemic coronary heart disease, stroke and peripheral macrovascular disease. The circulation system of pigs is similar to that of human, and AS can occur spontaneously with age, making it a good model for human AS research. This article combines the latest research on AS minipigs, as well as the research overview in the fields of AS vascular pathology research, intestinal flora research, inflammatory factor research, and metabolomics research.