基于SNP推断表型的法庭科学研究进展与展望

Research advances and prospect in SNP phenotyping in forensic science

  • 摘要: 随着犯罪嫌疑人反侦察能力的增强及检材复杂程度的增加,法医DNA表型推断在学科应用中被发掘,其中单核苷酸多态性(single nucleotide polymorphism,SNP)更是凭借其片段小、检测方法多等优点,在法庭科学中展现出极大发展潜力,有望将法庭科学推向新高度。但由于相关技术及分析方法的不成熟,需要大量的实验研究来提高其精确度,以达到实践运用的标准。本文将从色素特征、身高、面部特征、男性脱发4方面简述SNP推断表型的相关研究进展及其面临的挑战并对未来进行展望,为SNP的法庭科学应用提供参考。

     

    Abstract: With the enhancement of the suspect's counter-surveillance ability and the increase of the complexity of the samples, forensic DNA phenotypic inference has been explored in the disciplinary applications, among which single nucleotide polymorphism (SNP) has shown great potential for development in courtroom science by virtue of the advantages of its small fragment size and multiple methods, which is expected to push courtroom science to a new height. However, due to the immaturity of related technology and analysis methods, it needs a lot of experimental research to improve its accuracy to reach the standard of practical application. The progress of SNP inferred phenotypes, the challenges and future prospects of SNPs in terms of pigmentation, height, facial features, male pattern baldness, etc. are discussed in this paper, so as to provide references for the application of SNPs in courtroom science.

     

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