心理应激对胚胎植入的影响及反复种植失败患者的心理状况和干预策略综述

Review on effect of psychological stress on embryo implantation and psychological status and intervention strategies of patients with recurrent implantation failure

  • 摘要: 反复种植失败(recurrent implantation failure,RIF)是指不孕不育女性在经历多个体外受精-胚胎移植周期,并移植多枚优质胚胎后未能实现临床妊娠。研究表明,心理应激可以通过影响女性生殖内分泌激素调节子宫内膜局部微环境,引起子宫内膜功能障碍,导致RIF。另外,患者可能因为心理应激的增强,造成心理应激与不良妊娠结局的恶性循环。本文就心理应激对胚胎植入的影响以及RIF患者心理状况和干预策略进行系统综述。

     

    Abstract: Recurrent implantation failure (RIF) refers to infertile women who have undergone multiple in vitro fertilization embryo transfer cycles and failed to clinical pregnancy after transferring multiple high-quality embryos. Studies have shown that psychological stress not only affects female reproductive endocrine hormones, but also directly regulates the local microenvironment of the endometrium to cause endometrial dysfunction, which in turn leads to the occurrence of RIF and the increase of psychological stress in patients, resulting in a vicious cycle of psychological stress and adverse pregnancy outcomes. This article provides a systematic review on the effects of psychological stress on embryo implantation and psychological status and intervention strategies in patients with RIF.

     

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