气腹压导向的个体化呼气末正压设定与传统呼气末正压设定在老年患者腹部腔镜手术中应用的比较:一项前瞻性随机对照试验

Comparison of individualized positive end-expiratory pressure (PEEP) setting guided by pneumoperitoneum pressure and traditional peep setting in elderly patients undergoing laparoscopic abdominal surgery: A prospective randomized controlled trial

  • 摘要:
    摘要:背景 腹腔镜 CO2 气腹会导致肺泡在呼气相的闭合压力升高,若给予的呼气末正压(positive end-expiratory pressure,PEEP)不足则易导致机械通气过程中肺萎陷体积的增加,从而引发萎陷伤及气压伤。目前关于腹腔镜CO2气腹条件下的最佳PEEP一直尚无定论。目的 研究气腹压导向的个体化PEEP设定对老年腹部腔镜手术患者拔管后30min至术后3d内低氧血症发生率的影响。方法 选取2023年10月— 2024年4月解放军总医院第一医学中心择期全身麻醉下腹部腔镜手术的老年患者100例,采用随机数字表法将受试者分为两组:气腹压指导PEEP组(P组)和传统PEEP组(C组)。在机械通气过程中,P组在气腹期间采用与气腹压设定数值(mmHg)相等的PEEP(cmH2O);C组全程采用5cmH2O的PEEP至手术结束。主要结局指标:患者在拔管后30min及术后3d内低氧血症发生率。次要结局指标:患者在诱导后10min(T1)、气腹后10min(T2)、气腹后60min(T3)的驱动压、平台压、动态顺应性、氧合指数(PaO2/FiO2)和血流动力学数据等参数。结果 匹配后供纳入97例患者,其中P组纳入49例患者,平均年龄(67.9±6.5)岁;C组纳入48例患者,平均年龄(67.5±4.8)岁;两组一般资料差异无统计学意义(P>0.05)。P组术后低氧血症发生率显著低于C组10.4% (5/48) vs 30.6% (15/49),P=0.022;P组气腹后10min及60min的驱动压和动态顺应性显著优于C组;气腹解除后P组的氧合指数显著优于C组;两组血管活性药物的用量及液体输注总量无显著差异。结论 气腹压导向的个体化PEEP设定可降低老年腹部腔镜手术患者拔管后30min与术后3d内低氧血症发生率,改善术中呼吸力学及氧合指数。

     

    Abstract:
    Abstract: Background Laparoscopic CO2 pneumoperitoneum can elevate the closing pressure of alveoli during expiration. If the PEEP applied is insufficient, it can lead to an increase in the volume of lung collapse during mechanical ventilation, thereby inducing atelectasis and barotrauma. Therefore, a higher level of individualized PEEP is required to maintain alveolar open during expiration and reduce lung injury during CO2 pneumoperitoneum. However, there is no consensus on the optimal positive endexpiratory pressure (PEEP) during pneumoperitoneum. Objective To investigate the impact of individualized PEEP setting guided by pneumoperitoneum pressure on the incidence of hypoxemia from 30 minutes after extubation to 3 days postoperatively in elderly patients undergoing abdominal laparoscopic surgery. Methods A total of 100 elderly patients undergoing elective general anesthesia for abdominal laparoscopic surgery in the First Medical Center of Chinese PLA General Hospital from October 2023 to April 2024 were enrolled. The subjects were randomly allocated into two groups using a random number table method: the pneumoperitoneum pressure-guided PEEP group (P group, n=50) and the traditional PEEP group (C group, n=50). During mechanical ventilation, a PEEP level (cmH2O) equaling to the pneumoperitoneum pressure (mmHg) was used in the P group during the pneumoperitoneum period, while the C group used 5 cmH2O of PEEP throughout the procedure. The primary outcome was the incidence of hypoxemia from 30 minutes after extubation to 3 days postoperatively. The secondary outcomes included driving pressure, plateau pressure, compliance of respiratory system, oxygenation index (PaO2/FiO2), and hemodynamic data at 10 minutes after induction (T1), 10 minutes after pneumoperitoneum (T2), and 60 minutes after pneumoperitoneum (T3). Results A total of 97 patients were included in the final analysis. Among them, 49 patients were included in group P, with an average age of (67.9 ± 6.5) years; 48 patients were included in group C, with an average age of (67.5 ± 4.8) years. There was no statistically significant difference in patient demographics between the two groups (P > 0.05). The incidence of postoperative hypoxemia was significantly lower in the P group than that of the C group (10.4% 5/48 vs 30.6% 15/49, P=0.022). Driving pressure and dynamic compliance at 10 and 60 minutes after pneumoperitoneum were significantly better in the P group when compared to the C group. The PaO2/FiO2 after pneumoperitoneum deflation in the P group was significantly higher than the C group. There were no significant differences in the use of vasopressors or total fluid infusion between the groups. Conclusion Individualized PEEP setting guided by pneumoperitoneum pressure can reduce the incidence of postoperative hypoxemia, improve respiratory mechanics and PaO2/FiO2 during the surgery.

     

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