肺器官芯片在呼吸系统疾病诊治中的研究进展
Research progress of lung organ-on-a-chip in the diagnosis and treatment of respiratory diseases
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摘要:摘要：器官芯片作为医学界新兴的研究技术，在疾病的体外研究领域意义重大。其中，整合微流控器官芯片技术的肺器官芯片模型，在肺部疾病研究中显示出超越传统细胞培养和动物实验的显著优势，成为呼吸系统疾病研究领域前沿的体外模型。肺器官芯片能够体外模拟具有复杂病理生理过程的肺部微环境，在疾病机制研究、药物研发和个体化医疗方面具有广阔的应用前景。本文综述了肺器官芯片在肺损伤、肺部感染、肺纤维化、肺部肿瘤和气道疾病研究中的应用进展，并对未来的研究方向和器官芯片技术的发展前景进行了展望。Abstract:Abstract: Organ-on-a-chip technology, as an emerging research technique in the medical field, holds significant importance in the in vitro study of diseases. Among these, the lung organ-on-a-chip model integrated with microfluidic organ chip technology has demonstrated remarkable advantages over traditional cell culture and animal experiments in pulmonary disease research, becoming a cutting-edge in vitro model in the field of respiratory system diseases. The lung organ-on-a-chip can simulate the pulmonary microenvironment with complex pathophysiological processes in vitro and has broad application prospects in disease mechanism research, drug development, and personalized medicine. This paper reviews the application progress of lung organ-on-a-chip in the research of lung injury, pulmonary infection, pulmonary fibrosis, lung tumors, and airway diseases, and looks forward to future research directions.
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Keywords:
- lung /
- organ-on-a-chip /
- alveolar-capillary barrier /
- respiratory system diseases /
- Lung injury
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