Abstract: Background　The optimal fixation method for distal humeral fractures (DHF) remains controversial. Current biomechanical studies mainly focus on evaluating the stiffness and stability of different fixation techniques, while dynamic analysis over the entire healing period is lacking.Objective　This study aims to comprehensively evaluate the biomechanical conditions of different fixation methods (parallel plating vs. orthogonal plating) during the healing process of distal humeral fractures, to enhance understanding of plate configuration selection. Furthermore, it seeks to inform appropriate postoperative restrictions during fracture healing and rehabilitation to achieve better treatment outcomes for DHF.Methods　A finite element (FE) model of a distal humeral fracture was constructed based on elbow CT data from a healthy 30-year-old male. Models of parallel and orthogonal plating were developed, along with a transient callus model based on computational mechanics. Finite element analysis using ANSYS software was conducted at different healing stages (immediately postoperative, and at 1, 3, and 6 months postoperatively) to evaluate relative displacement at the fracture site, peak callus stress, and maximum stress distribution within the humerus and fixation constructs. Simulations incorporated three types of loading conditions to mimic daily elbow activities: axial, bending, and varus loading. Results　In the early postoperative period (0–3 months), the parallel plating group showed significantly greater fracture site displacement under axial and bending loads compared to the orthogonal plating group, whereas it exhibited less displacement under varus loading. At 0 and 1 month postoperatively, the peak callus stress in the parallel plating group was lower than that in the orthogonal plating group. Additionally, the fixation construct in the orthogonal group experienced higher stress levels early after surgery, which gradually decreased over time. The orthogonal plating configuration exhibited a more uniform stress distribution, with displacement and stress levels maintained within a favorable range. These findings suggest that parallel plating offers superior initial stiffness and stability, while orthogonal plating provides more reliable long-term performance during later healing stages. Conclusion　Finite element analysis indicates that parallel plating offers higher stiffness and stability in the early postoperative period but may lead to stress concentration within the fixation construct, potentially increasing the risk of complications. In contrast, orthogonal plating demonstrates more uniform stress distribution and greater reliability during later stages of fracture healing. Clinical decision-making regarding fixation strategies should consider the patient's individual needs and the entire healing timeline to optimize treatment outcomes.