Abstract: PANoptosis, as a newly discovered form of programmed cell death, integrates the characteristics of pyroptosis, apoptosis, and necroptosis. However, it is not a simple superposition of these forms of cell death but has a unique biological process that cannot be fully covered by any single type among them. The PANoptosome is assembled from multiple proteins and participates in programmed cell death patterns such as pyroptosis, apoptosis, and necroptosis through signal transduction. It interacts with key molecules to regulate the process of PANoptosis. Researches show that PANoptosis is closely related to diseases such as cardiomyopathy, septic cardiomyopathy, heart failure, myocardial ischemia-reperfusion injury, atherosclerosis, and thoracic aortic aneurysm. Therefore, this review will focus on elucidating the molecular mechanism and occurrence process of PANoptosis and its internal connection with cardiovascular diseases.