Abstract: Background　Existing dural repair materials often fail to simultaneously meet the requirements of adhesive sealing and postoperative anti-adhesion.Objective　To construct a bifunctional PC-HAA Janus membrane for dural repair and to evaluate its in vitro repair-related properties.Methods　A PC-HAA Janus membrane was fabricated using a PCL/CS electrospun membrane as the non-adhesive top layer and an HA-GMA/AA-NHS adhesive hydrogel as the bottom layer. The structural characteristics of the material were observed by macroscopic morphology and scanning electron microscopy. Its wet-tissue adhesion and pressureresistant sealing performance were evaluated by 180° peel burst pressure tests. Protein adsorption, live/dead staining, CCK-8 assay, and cell migration assay were used to assess its interfacial characteristics and in vitro cytocompatibility.Results　The prepared PCHAA Janus membrane exhibited a stable bilayer structure and distinct interfacial functional differentiation. Under wet conditions, the material showed good adhesive fixation and pressure-resistant sealing capability, while its outer surface exhibited low protein adsorption. In vitro experiments demonstrated that the membrane had good cytocompatibility and exerted an inhibitory effect on fibroblast migration.Conclusion　The PC-HAA Janus membrane can achieve dual functional synergy, namely adhesive sealing on the tissue-contacting side and an anti-adhesion barrier on the outer side, indicating its potential for dural repair.