正常眼轴白内障患者中浅前房与晶状体悬韧带异常的关联分析及预测价值研究

Association and predictive value of shallow anterior chamber and zonular abnormalities in cataract patients with normal axial length

  • 摘要: 背景 晶状体悬韧带异常患者白内障术后易出现并发症。临床上晶状体悬韧带异常在浅前房中较为常见,而浅前房多见于短眼轴。但临床发现部分眼轴正常(22 ~ 24 mm) 但合并浅前房的白内障患者同样存在晶状体悬韧带异常。目的 探讨在眼轴长度22 ~ 24 mm的白内障患者浅前房与晶状体悬韧带异常的关联,并评估中央前房深度(central anterior chamber depth,ACD) 联合晶状体厚度(Lens thickness,LT) 对悬韧带异常的诊断价值。方法 回顾性分析2024 年10 月至2025 年12 月于解放军总医院第一医学中心行白内障超声乳化吸除术、人工晶状体植入术,且眼轴长度在22 ~ 24 mm范围内的白内障患者的单眼临床资料。通过超声生物显微镜(ultrasound biomicroscope,UBM) 或术中记录评估晶状体悬韧带状态,采用多元logistic 回归模型评估浅前房与晶状体悬韧带异常的关系。采用ACD及LT构建单项、串联、并联诊断模型,计算各模型诊断效能并通过ROC曲线评价模型稳定性。结果 共纳入138 例(138 眼),其中浅前房组73 例[男28 例、女45 例,平均年龄(71.2±9.5) 岁],正常前房组65 例[男28 例、女37 例,平均年龄(64.2±11.5) 岁],两组性别构成差异无统计学意义,但浅前房组年龄高于正常前房组(P<0.001)。浅前房组悬韧带异常率为94.5%(69/73),显著高于对照组的43.1% (28/65;P<0.001)。logistic 回归结果表明ACD (OR=1.28,95% CI:1.14 ~ 1.44,P<0.001)、晶状体厚度(OR=1.32,95% CI:1.15 ~ 1.52,P<0.001) 与悬韧带异常独立关联。诊断模型分析显示:ACD 单项标准的敏感度为71.1%,特异度为90.2%,曲线下面积(area under the curve,AUC) 为0.807;LT 单项标准的敏感度为58.8%,特异度为87.8%,AUC 为0.733;并联标准的敏感度最高(76.3%),AUC 为0.796,适用于术前初筛;串联标准的特异度最高(95.1%),阳性预测值为96.3%,AUC为0.744,适用于确诊高危患者。Bootstrap 内部验证提示模型稳定性尚可。结论 在正常眼轴白内障患者中,浅前房是悬韧带异常的重要提示征象。联合ACD与LT构建的分层诊断策略可有效识别悬韧带异常风险,有助于指导个体化手术方案的制定。

     

    Abstract: Background Patients with lens zonular abnormalities are prone to postoperative complications following cataract surgery. Clinically, zonular abnormalities are relatively common in eyes with shallow anterior chambers, which are typically associated with short axial lengths. However, clinical observations have revealed that certain patients with normal axial length (22 – 24 mm) but concomitant shallow anterior chambers also present with lens zonular abnormalities. Objective To investigate the association between shallow anterior chamber and lens zonular abnormalities in cataract patients with axial lengths of 22–24 mm, and to evaluate the diagnostic value of combining central anterior chamber depth (ACD) and lens thickness (LT) for zonular abnormalities.Methods A retrospective analysis was conducted on monocular clinical data from cataract patients who underwent phacoemulsification and intraocular lens implantation at the First Medical Center of Chinese PLA General Hospital between October 2024 and December 2025, with axial lengths ranging from 22.0 to 23.99 mm. Zonular status was assessed via ultrasound biomicroscope (UBM) or intraoperative records. Multivariable logistic regression models were used to evaluate the relationship between shallow anterior chamber and zonular abnormalities. Single, serial, and parallel diagnostic models were established using ACD and LT cut-off values. Diagnostic performance metrics were calculated for each model, and model stability was evaluated using ROC curve analysis.Results A total of 138 patients (138 eyes) were enrolled, including 73 in the shallow ACD group (28 men and 45 women; mean age of 71.2±9.5 years) and 65 in the control group (28 men and 37 women; mean age of 64.2±11.5 years). No significant difference in gender distribution was observed between the two groups (P>0.05), but the shallow ACD group were older (P<0.001). The incidence of zonular abnormalities was significantly higher in the shallow ACD group (94.5%, 69/73) than in the control group (43.1%, 28/65; P<0.001). Logistic regression analysis demonstrated that ACD (OR=1.28, 95% CI: 1.14 – 1.44, P<0.001) and LT (OR=1.32, 95% CI: 1.15 – 1.52, P<0.001) were independently associated with zonular abnormalities. Diagnostic model analysis revealed: the single ACD criterion yielded a sensitivity of 71.1%, specificity of 90.2%, and AUC of 0.807; the single LT criterion yielded a sensitivity of 58.8%, specificity of 87.8%, and AUC of 0.733; the parallel criterion achieved the highest sensitivity (76.3%) and AUC of 0.796, making it suitable for preoperative screening; the serial criterion achieved the highest specificity (95.1%) and positive predictive value (96.3%), with AUC of 0.744, making it suitable for identifying high-risk surgical candidates. Bootstrap internal validation indicated acceptable model stability. Conclusion  In cataract patients with normal axial length, shallow anterior chamber is a significant indicator of zonular abnormalities. A stratified diagnostic strategy combining ACD and LT can effectively identify the risk of zonular abnormalities and facilitate the development of individualized surgical plans.

     

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