颞下颌关节盘前移位的MRI图像深度学习诊断模型的构建

Construction of a deep learning model for MRI images of anterior disc displacement of temporomandibular joint

  • 摘要: 背景 颞下颌关节紊乱病是常见的口颌面疾病,发病率为20% ~ 60%,且呈逐年上升的趋势,其诊断仍是临床难题。目的 构建能够自动识别颞下颌关节盘前移位的磁共振成像(magnetic resonance imaging,MRI)图像深度学习模型,提高临床阅片效率。方法 回顾性收集2020 年10 月至2024 年10 月在解放军总医院第一医学中心口腔科就诊,MRI检查确诊为颞下颌关节盘前移位患者249 例,共收集2 002 张颞下颌关节盘前移位MRI 图像,2 名颞下颌专病医生通过Materialize Mimics Medical 软件对颞下颌关节区域识别并进行手动标记分割MRI图像扫描的张口位及闭口位斜矢状位图片,将MRI图像按是否移位分组。构建基于密集卷积注意力U-Net 深度学习模型(颞下颌关节盘分割模型和颞下颌关节盘前移位分类模型),通过交叠度(intersection over union,IoU)与Dice 系数评价分割模型的性能;通过准确率、精确率与召回率评估深度学习分类模型的性能。结果 构建了颞下颌关节盘深度学习分割模型,其验证集平均IoU 值为0.912±0.004(95% CI:0.906 ~ 0.918),平均Dice 系数为0.925±0.005(95% CI:0.920 ~ 0.930)。针对关节盘前移位构建分类模型,分类模型平均召回率为0.918±0.017(95% CI: 0.894 ~ 0.937)、精确率为0.819±0.007(95% CI: 0.810 ~ 0.833)、F10.866±0.009(95% CI: 0.854 ~ 0.878)、曲线下面积(area under the curve,AUC)0.721±0.015(95% CI:0.702 ~ 0.740),平均真阳性率0.916,平均假阳性率0.465,组间差异具有统计学意义(P=0.015、P=0.033)。结论 构建的深度学习模型具备良好的分割和分类性能,可自动识别颞下颌关节盘前移位(二分类:有无移位),为颞下颌关节盘前移位的智能辅助诊断提供了可行工具。

     

    Abstract: Background Temporomandibular joint disorder (TMD) is a common oral and maxillofacial disease with an incidence ranging from 20% to 60%, and its prevalence has been increasing year by year. Accurate diagnosis of this condition remains a major clinical challenge.Objective To develop a deep learning model based on magnetic resonance imaging (MRI) for the automatic identification of anterior temporomandibular joint disc displacement, so as to improve the efficiency of clinical image reading. Methods A total of 249 patients diagnosed with anterior temporomandibular joint disc displacement via MRI from October 2020 to October 2024 at the Department of Stomatology, the First Medical Center of PLA General Hospital were retrospectively enrolled, yielding a total of 2 002 oblique sagittal MRI scans (both open-mouth and closed-mouth positions). Two specialists in temporomandibular joint disorders manually segmented and annotated the temporomandibular joint regions using Materialise Mimics Medical software, and all MRI images were grouped according to the presence or absence of disc displacement. A dense convolutional attention U-Net framework was established, including a segmentation model for temporomandibular joint discs and a classification model for anterior disc displacement. The segmentation performance was evaluated using the intersection over union (IoU) and Dice coefficient, while the classification performance was assessed via accuracy, precision and recall.Results  For the deep learning segmentation model of temporomandibular joint discs, the mean IoU on the validation set was 0.912 ± 0.004 (95% CI: 0.906 - 0.918), and the mean Dice coefficient was 0.925 ± 0.005 (95% CI: 0.920 - 0.930). For the classification model of anterior disc displacement, the mean recall, precision, F1-score and area under the receiver operating characteristic curve (AUC) were 0.918 ± 0.017 (95% CI: 0.894 - 0.937), 0.819 ± 0.007 (95% CI: 0.810 - 0.833), 0.866 ± 0.009 (95% CI: 0.854 - 0.878) and 0.721 ± 0.015 (95% CI: 0.702 - 0.740), respectively. The mean true positive rate (TPR) was 0.916 and the mean false positive rate (FPR) was 0.465. Inter-group differences were statistically significant (P=0.015, P=0.033). Conclusion The constructed deep learning model shows favorable segmentation and classification performance, enabling automatic identification of anterior disc displacement of the temporomandibular joint (binary classification: presence or absence of displacement). It provides a feasible tool for the intelligent auxiliary diagnosis of anterior disc displacement of the temporomandibular joint.

     

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