文拉法辛治疗慢传输型便秘的临床研究
Clinical study on venlafaxion hydrochloride in the treatment of slow-transit constipation
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摘要: 目的: 探讨精神心理异常与慢传输型便秘(STC)的关系及抗抑郁药治疗对慢传输型便秘的影响。方法: 根据便秘与精神心理异常的因果关系,将STC患者分为三组,分别服用文拉法辛(C组)、聚乙二醇4000(B组)及文拉法辛和聚乙二醇4000(A组),比较治疗前后HAMA、HAMD评分、大便性状、排便次数及胃肠通过时间测定(GITT)变化。结果: 文拉法辛及聚乙二醇4000对GITT无影响。各组治疗后精神心理评分均较治疗前显著降低,且A组和C组下降更为显著。粪便次数和性状的改善A组和B组明显优于C组。结论: 精神心理异常与STC发病及治疗密切相关。采用抗抑郁药联合渗透性缓泻剂是治疗STC有效的方法。Abstract: Objective: To evaluate the relationship between psychophysiologic disorders and slow-transit constipation （STC） and the efficacy of antidepressive agents in the treatment of STC. Methods: According to the relationship between psychophysiologic disorders and constipation, 114 patients with STC were divided into three groupswhich received venlafaxion hydrochloride（C group）, polyethylene glycol 4000（PEG4000）（B group） or both of them（A group） respectively.HAMA score,HAMD score, stool form and frequency and gastrointestinal gut transit time（GITT） were assessed before and at the end of treatment.（Results: Venlafaxion） hydrochloride and PEG4000 had no effect on GITT. Compared with pretreatment, HAMA and HAMD score decreased significantly at the end of treatment and their decrease in A and C group were greater, the improvement of stool form and stool frequency in A and B group were greater significantly than C group.Conclution: Psychophysiologic disorders are highly related to the occurrence and treatment of SCT. Combined antidepressive agents and laxatives may be effective in the treatment of SCT.
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