Abstract: Ojbective: To investigate the relationship between levels of coagulation factors and classification of inflammation and pathological phases in patients with chronic hepatitis B.Methods: Eighty-three patients with chronic hepatitis B proved by liver biopsy were examined.A series of coagulation tests including prothrombin activity（PA）,activated partial thromboplastin（APTT）.factor Ⅱ、Ⅴ、Ⅶ、Ⅷ、Ⅸ、Ⅹ and vWF assay were performed.Results: The levels of prothrombin time activity in patients with chronic hepatitis B were significantly lower from inflammation G₂ and pathological S2 than in control group（P＜0.05）;FactorⅡand Ⅶ were significantly lower in inflammation phase G₃₊₄ than control group（P＜0.05）;Factor Ⅷ was significantly higher from inflammation phase G₁ to G₄ than control group（P＜0.01）;Factor vWF was significantly higher from inflammation phase G₂ to G₄ than control group（P＜0.05）;Factor Ⅱ was significantly lower from pathological S3 than in control group（P＜0.05）;Factor Ⅹ was significantly lower in pathological S4 than control group（P＜0.05）;Factor Ⅷ and vWF were significantly higher from pathological S1 than control group（P＜0.05）;Conclusions: The levels of prothrombin time activity,Factor Ⅱ、Ⅷ、Ⅹ and vWF could reflect the severity of degree of inflammation and hepatic fibrosis in patients with chronic hepatic B.