Abstract: Objective To study the effects of energy and protein intake on serum albumin level in bedridden old male inpatients. Methods Clinical data about 37 bedridden old male patients in our hospital were retrospectively analyzed.They were allocated into low serum albumin(LA) group(serum albumin<35g/L,n=22) and normal serum albumin(NA) group(serum albumin ≥ 35g/L, n=15).Energy and protein intake,nitrogen balance,hemoglobin level and lymphocytes were compared between the two groups. Results No significant difference was observed in energy and protein intake between the two groups(22.42±4.62kcal/(kg·d)(1kcal=4.184J) and(0.99±0.23)g/(kg·d) vs(22.37±4.25)kcal/(kg·d) and(0.92±0.18)g/(kg·d)),but the nitrogen balance value and hemoglobin level were significantly lower in LA group than in NA group((-1.17±2.35) and(108.23±12.07)g/L vs(1.07±1.46) and(123.87±18.97)g/L,P<0.05).The percentage of patients with negative nitrogen balance and anemia was significantly higher in LA group than in NA group(59.1% and 63.8% vs 26% and 20%,P<0.05). Conclusion Sufficient energy and protein intake cannot improve the serum albumin level in bedridden old male inpatients.Patients with hypoalbuminemia are easy to have complications of negative nitrogen balance and anemia.The reasons of hypoalbuminemia need to be further studied.