Abstract: Objective To observe the effect of dezocine on tracheal catheter removal after epigastic operation under general anesthesia,including stress,consciousness,and recovery of respiration. Methods Eighty patients undergoing epigastric operation were randomly divided into dezocine group(group D) and control group(group C),40 in each group.Etomidate and remifentanil were withdrawn from the patients in group D 15 and 3min respectively before operation,who were then infused with dezocine(5mg) through the vein 15min by the end of operation.Patients in group C were infused with 5ml 0.9% sodium chloride solution.Their SBP,DBP,MAP,and HR were measured before operation(T₀),1 minute after operation(T₁),3 minutes after operation(T₂) and 5 minutes after operation(T₃).Their RPP was calculated.Blood sample was collected from internal jugular vein.Blood glucose and cortisol levels were measured by glucose-oxidase and radioimmunoassay.Wakeup and tracheal catheter removal time,and dysphoria during tracheal catheter removal were recorded. Results The MAP,HR and RPP were significantly lower in group C than in group D at T₁-T₃(P<0.05).The blood glucose and cortisol levels were significantly higher in group D than in group C at T₁-T₃(P<0.05).The incidence of dysphoria was significantly lower in group D than in group C during tracheal catheter removal(P<0.05).No significant difference was found in wakeup and tracheal catheter removal time between the two groups(P>0.05). Conclusion Intraveinous injection of dezocine can inhibit stress to tracheal catheter removal under general anesthesia without affecting the wakeup and respiration recovery of patients.