Abstract: Objective To assess the correlation between glutathione S-transferase M1(GSTM1) polymorphism and risk of developing lung cancer in non-smoking Chinese by meta-analysis. Methods Papers on the correlation between GSTM1 polymorphism and risk of lung cancer in non-smoking Chinese were searched from CNKI(1979-2011),CQVIP(1989-2011),Chinese Biomedical Literature Database(1979-2011),Wanfang Database(1998-2011),EMbase(1900-2011) and PubMed(1966-2011). Results Sixteen papers on case-control study were included in this study,involving 818 non-smoking patients with lung cancer and 921 healthy controls.Meta-analysis showed that the risk of developing lung cancer was significantly higher in non-smoking Chinese with GSTM1-deficit genotype than in those without GSTM1-deficit genotype(OR=1.65,95%CI=1.34,2.04).Egger's and Begg's analysis showed that the risk of developing lung cancer was 1.48-fold(95%CI=1.14,1.91) and 2.03-fold(95%CI=1.42,2.90) higher in Chinese of both South and North China with GSTM1-deficit genotype than that in controls. Conclusion The risk of developing lung cancer is significantly higher in non-smoking Chinese with GSTM1-deficit genotype.