Abstract: Objective To study the effect of controlled low central venous pressure on heart rate variability(HRV) and hemodynamics of patients during hepatectomy. Methods Twenty-nine ASAⅠ-Ⅱpatients underwent elective hepatectomy with controlled low central venous pressure technique under venous-inhalation general anesthesia.Their MBP,HR,BIS,HF,LF,and HF/LF ratio were recorded before anesthesia(T₀) and before deliberate hypotension(T₁),Immediately(T₂),at 5min(T₃),10min(T₄) and 15min(T₅) after CVP <5mmHg(1mmHg=0.133kPa),and immediately(T₆),at 5min(T₇),10min(T₈) and 15min(T₉) after CVP>5mmHg. Results The LF/HF ratio was higher at 10min after pressure restore than its basic value(P<0.05).However,no significant difference was found in the LF/HF ratio and its basic value at the other time points.The HF was lower at T₈ than at T₆(P<0.05).The LF/HF was higher at T₈-T₉ than at T₆(P<0.05).The HR was higher at T₄ than at T₀(P<0.05).The mean blood pressure was lower at T₁-T₉ than at T₀(P<0.05). Conclusion Venous-inhalation general anesthesia exerts no significant effect on the autonomic nervous system of patients during hepatectomy with controlled low central venous pressure technique under venous-inhalation general anesthesia and can maintain their normal sympathetic and parasympathetic tone,blood pressure and mean blood pressure.