Abstract: Objective To study the effect of aspirin on serum high sensitive C-reactive protein（hs-CRP）in type 2 diabetes mellitus（T2DM） patients and its relation with diabetic nephropathy. Methods One hundred and seven T2DM patients were randomly divide into group A（n=48） and group B（n=59）.Patients in group A took 100mg aspirin per os/night and those in group B received routine anti-diabetic therapy for 12 months,then serum levels of hs-CRP,urinary albumin excretion rate（UAER）,fast blood glucose（FBG）,glycosylated hemoglobin（HbA1c）,fasting insulin（INS）,fasting C peptide,triglyceride（TG） and total cholesterol（TC） were measured. Results No significant difference was found in serum levels of FBG,HbA1c,INS,fasting C peptide,TG and TC between the two groups（P＞0.05）.The serum hs-CRP level was lower while the serum UAER level was higher in group A after treatment than before treatment（P＜0.05）.The serum hs-CRP and UAER levels were higher in group B after treatment than before treatment（P＜0.01）.The serum hs-CRP and UAER levels were higher in group B than in group A（P＜0.01）. Conclusion Aspirin can reduce the serum hs-CRP level in T2DM patients and plays a certain role in prevention and prediction of diabetic nephropathy.