Abstract: Objective To analyze the clinical diagnosis and treatment of pseudomyxoma peritonei（PMP）. Methods Clinical diagnosis and treatment of 52 PMP patients admitted to our hospital from 2001 to 2011 and their follow-up data were retrospectively analyzed. Results The 52 PMP patients were found to have abdominal bulge,distension and pain,which were confirmed in 43 by ultrasound,CT and abdominal paracentesis biopsy.The patients recovered quite well except 2 who died after operation.Forty-five patients were followed up for 2 months-11 years,during which 7 died. Conclusion Although PMP is a low malignant tumor,its mortality is high.Combined ultrasound,CT and abdominal paracentesis biopsy contributes to its definite diagnosis before operation.Cytoreduction is the first choice of treatment for it.Modification of its resection range can reduce the incidence of complications and improve the survival rate of PMP patients.