Abstract: Objective To study the diagnosis and treatment of pulmonary sequestration. Methods Clinical data about 18 patients with pulmonary sequestration admitted to our hospital from July 2008 to February 2011 were retrospectively analyzed. Results The main clinical symptoms of intra-lobar pulmonary sequestration were cough and expectoration with blood-tinged sputum,fever and chest pain.Of the 18 patients,16（88.8%） were diagnosed as intra-lobar pulmonary sequestration,1（5.6%） was diagnosed as extralobar pulmonary sequestration and 1 case（5.6%） was diagnosed as pulmonary sequestration with its type unclassified.The lesion was located in the left lower lung lobe of 11 patients and in the right lower lung lobe of 7 patients.Radiological examination revealed that the blood supply was abnormal for the lesion in 11 patients（61.1%）.Fifteen patients（83.3%） underwent surgical treatment. Conclusion The main clinical symptoms of pulmonary sequestration are cough and expectoration.Abnormal blood supply for the lesion is the key to its diagnosis and surgical treatment is effective for it.