Abstract: Objective To observe the effect of slow amnesia analgesia induction on endotracheal intubation-induced QTc interval and hemodynamic parameters in elderly coronary heart disease（CHD） patients. Methods Sixty ASA II CHD patients aged 6080 years were randomly divided into slow amnesia analgesia induction group（group J） and routine induction group（group C）,30 in each group.Patients in group J were treated with slow amnesia analgesia induction and those in group C were treated with common rapid intravenous induction.Basic data before endotracheal induction（T0）,2min before endotracheal intubation（T1）,1min before endotracheal intubation（T2）,immediate endotracheal intubation（T3）,30s after endotracheal intubation（T4）,2 min after endotracheal intubation（T5）,5min after endotracheal intubation（T6）,corrected QTc interval,mean artery pressure（MAP） and heart rate（HR） were recorded and analyzed. Results The fluctuation of QTc interval,MAP and HR was more stable in group C than in group J（P＜0.05）.The QTc interval was significantly longer in group C than in group J after intubation at T4-T6 than after intubation at T0（P＜0.05）.The T4-T6 were significantly shorter in group C after intubation than before intubation（P＜0.05）.The incidence of abnormal QTc interval was significantly lower in group J than in group C after intubation at T4-T6（P＜0.05）. Conclusion Slow amnesia analgesia induction can effectively shorten endotracheal intubation-induced QTc interval and decrease hemodynamic reactions during endotracheal intubation.