Abstract: Objective To study the correlation between aspirin resistance and prognosis in elderly male patients with cardiovascular diseases（CVD）. Methods Three hundred and four elderly male CVD patients at the age of 75.03±7.77 years were enrolled in this study.The patients were treated over one month with oral aspirin（≥75mg daily） and followed up for a median time of 1.8 years. Results Light transmission aggregometry（LTA） showed that 131 patients（43.1%） were insensitive to aspirin,25（8.2%） were sensitive to aspirin,and 106（34.9%） were semi-sensitive to aspirin.The incidence of adverse events was higher in patients who were insensitive to aspirin than in those were sensitive to aspirin（18.3% vs 9.8%,HR=1.864,95%CI: 1.046-3.324,P=0.039）.Cox proportional hazard regression model demonstrated that aspirin insensitivity（HR=3.050,95% CI: 1.464-6.354,P=0.003） and diabetes mellitus（HR=2.055,95% CI: 1.060-3.981,P=0.033） were correlated with adverse events. Conclusion The risk of adverse events tends to increase in elderly male CVD patients who are insensitive to aspirin.