Abstract: Objective To analyze the effect of intensity-modulated radiotherapy（IMRT） on nasopharyngeal carcinoma. Methods Eighty-nine patients with nasopharyngeal carcinoma（14 at stage Ⅰ,46 at stage Ⅱ,28 at stage Ⅲ,and 1 at stage Ⅳ a） admitted to our hospital from October 2007 to October 2010 underwent IMRT at the dose of 60-65Gy for the gross tumor volume（PTV） of nasopharyngeal carcinoma,which was increased to 70-75Gy according to the reduced PTV of nasopharyngeal carcinoma.The dose of IMRT was 65-70Gy,52Gy,36.5Gy,47.2Gy or 43.4Gy,40.1Gy or 39.6Gy,and ＜30Gy,respectively,for nasopharyngeal carcinoma at middle and low neck,supraclavicular area,brainstem and spinal cord,left or right optic nerve,left or right parotid,and 50% of parotid. Results The median follow-up time of patients was 34 months.Local or lymph nasopharyngeal carcinoma reoccurred in 7 patients.The 1-and 2-year local recurrent rate of nasopharyngeal carcinoma was 2.2% and 6.7%,respectively.The 1-,2-and 3-year survival rate of the patients was 98.9%,96.6% and 93.2%,respectively.The main acute reactions in the patients were radiation injury of oral mucosa,bone marrow suppression and xerostomia.Radiation injury of oral mucosa at gradesⅠ,Ⅱ and Ⅲ accounted for 19.1%,49.4% and 31.4%,respectively.Bone marrow suppression at gradesⅠ,Ⅱ and Ⅲ was 47.2%,16.9% and 20.2%,respectively.No sequel of radiation cerebral injury was observed in all patients. Conclusion IMRT can achieve satisfactory dose distribution in different areas of nasopharyngeal carcinoma and improve its local control rate and 2-and 3-year survival rate,and is thus a standard treatment modality for nasopharyngeal carcinoma.