Abstract: Objective To study the correlation between coronary lesion and biochemical parameters in patients with simple coronary heart disease (CHD). Methods One hundred and ninety-four patients with suspected CHD but without other diseases were divided into CHD group and control group according to their coronary angiography. CHD group was further divided into single coronary lesion group(CHD 1 group) and multi-coronary disease group (CHD 2 group) according to its coronary lesions. Differences in biochemical parameters were compared between the two groups. Results The serum levels of N-terminal brain natriuretic peptide(NTBNP), lipoprotein a(Lpa), cardiac troponin T(TNT), glucose(GLU), urea nitrogen(BUN), creatinine(CRE) were significantly higher while the serum levels of apolipoprotein-A1(Apo-A1) and high density lipoprotein cholesterol(HDL-C) were significantly lower in CHD group than in control group(P< 0.01, P< 0.05), which were positively related with the coronary lesions. Conclusion The metabolism of serum GLU, BUN, CRE changes in patients with simple CHD but without hepatic and kidney disease, diabetes and other diseases. The serum NTBNP and TNT are correlated with early CHD. Apo-A1 and HDL-C are the protection factors for CHD.