Abstract: Objective To study the value of prenatal ultrasonography for the diagnosis of fetal limb deformity. Methods Sixty-three delivered fetuses with limb deformity detected by ultrasonography and 5 467 induced fetuses with normal extremities in our hospital from March 2009 to March 2012 were followed up. Results Of the 63 fetuses with limb deformity, 29 were found with lower limb deformity(13 with clubfoot deformity, 1 with split foot, 2 with apodia, 10 with femur benting, 1 with congenital absence of lower limbs, 1 with absence of fibula, 1 with polydactyl), 13 with upper limb deformity(2 with achiria, 5 with hand deformity, 4 with absence of radius, 2 with forearm short benting), 8 with lethal skeletal dysplasia, 11 with short limb deformity, 1 with camplomelic dysplasia, 1 with 6 fingers and 6-toe deformity. Chromosome was detected in 15 fetuses (trisomy-18 in 2 and trisomy-21 in 2).Missed diagnosis of sixteen fetuses with finger-toe deformity were made by ultrasonography from March 2009 to March 2012. Conclusion Fetal limb deformity is a common congenital deformity, including a various types. Systematic consecutive follow-up ultrasonography can increase its detection rate and reduce its misdiagnosis rate, thus contributing to its prenatal ultrasonographic diagnosis.