Abstract: Objective To study the clinicopathological features of duodenal neuroendocrine carcinoma (DNEC) and its surgical treatment outcome. Methods Clinical data about 8 DNEC patients and its surgical treatment outcome were retrospectively analyzed with its related literature reviewed. Results Of the 8 DNEC patients, 5 were males and 3 were females. They developed DNEC at the age of 53 years (mean 28-80 years). DNEC was mainly manifested as jaundice in 5 cases, as abdominal pain in 5 cases, and as melena in 1 case. No symptom was observed in 1 case. The tumor was located at descendant duodenum in 4 cases, at duodenal papilla in 3 cases, at horizontal duodenum in 1 case. CT scan showed DNEC at duodenal papilla or its corresponding sites. Of the 8 patients, 4 underwent pancreaticoduodenectomy, 2 underwent ERCP and bile duct stenting, 2 underwent gastroenterostomy and PTCD. The patients were followed up for 3-40 months after operation. The 4 patients who underwent radical excision were still alive while the other 4 patients who underwent palliative therapy died. Conclusion DNEC is an infiltrative growth tumor. Surgical resection can improve the prognosis of its patients.