Abstract: Objective To provide the evidence for infected joints after artificial joint replacement by analyzing the bacteria infecting artificial joints and their drug sensitivity. Methods Seventy strains isolated from bloodsamples of patients with infection after artificial joint replacement (admitted to our hospital from May 2011 to March 2012) and their drug sensitivity were retrospectively analyzed. Results The major bacteria infecting joints after artificial joint replacement were coagulase-negative staphylococci followed by staphy-lococcus aureus, Gram-positive bacilli, Pseudomonas aeruginosa, staphylococcus epidermidis, and Escherichia coli, accounting for 37.14%, 15.71%, 8.57%, 5.71%, 5.71% and 4.29% respectively.These bacteria were most sensitive to vancomycin, linezolid, imipenem and highly resistant to erythrocin, penicillin, amoxicillin and cotrimoxazole. Conclusion Bacteria infecting artificial joints are mainly the Gram-positive bacteria.Vancomycin, linezolid and (or) imipenem are the first choice of treatment for infected joints after artificial joint replacement, which should be adjusted according to their drug sensitivity.