Abstract: Objective To study the clinical characteristics and prognosis of patients with cardiac amyloidosis(CA). Methods Clinical data about 62 CA patients admitted to our hospital were retrospectively analyzed.Independent risk factors for the prognosis of CA patients were analyzed according to the COX regression model. Results The CA patients presented a variety of clinical manifestations.Low voltage in limb leads and poor R wave progression in precordial leads were frequently observed on ECG.UCG showed thicker interventricular septum, concentric left ventricular hypertrophy and diastolic dysfunction, enhanced echo of myocardial granules, And CMR reveal different patterns of abnormal late gadolinium enhancement(LGE).Cox regression analysis showed that NYHA classification, E/A> 1.5 and DT< 150 ms were the influencing factors for the prognosis of CA patients. Conclusion The clinical manifestations of CA patients lack of specificity.CA can be diagnosed by biopsy of exocardial tissue in combination with ECG, UCG and CMR.The prognosis of CA patients is poor.NYHA classification, E/A> 1.5 and DT< 150 ms are the influencing factors for the prognosis of CA patients.