Abstract: Objective To study the clinical characteristics of peritoneal pseudomyxoma and the relative risk factors for its postoperative complications. Methods Thirty-nine peritoneal pseudomyxoma patients admitted to our hospital from 2002 to 2011 were included in this study.Their clinical data, including its postoperative complications and its prognosis-inf luencing factors were retrospectively analyzed. Results Of the 39 patients, 17 (43%) developed complications after operation such as intestinal obstruction and intra-abdominal infection, 25 had recurrence with a median recurrence time of 12 months.The risk to develop complications after operation increased when the ECOG score was ≥1 (P< 0.05).No signif icant difference was observed in gender, age, operation time and hyperthermic intraperitoneal chemotherapy (HIPEC) among the patients (P> 0.05).Univariate and multivariate analyses showed that the peritoneal pseudomyxoma was pathologically typed as disseminated peritoneal adenomueinosis(DPAM).Operation in combination with HIPEC could delay its recurrence (P< 0.05). Conclusion Postoperative complications of peritoneal pseudomyxoma should be prevented in patients with their ECOG score ≥1.Operation in combination with HIPEC can delay the recurrence of DPAM.