Abstract: Objective To observe the thrombelastography (TEG) and coagulation parameters in chronic kidney disease (CKD)patients. Methods Ninety CKD patients were divided into stage 1-2 CKD group, stage 3 CKD group, stage 4 CKD group, non-hemodialysis stage 5 CKD group and dialysis stage 5 CKD group.Their TEG and coagulation parameters were analyzed. Results The plasma levels of fibrinogen and its D-dimer were significantly higher whereas the plasma antithrombase Ⅲ level was significantly lower in non-hemodialysis stage 5 CKD group and dialysis stage 5 CKD group than in stage 1-2 CKD group and stage 3 CKD group (P＜ 0.05).TEG showed that the reaction time and K-time were significantly shorter in dialysis stage 5 CKD group than in stage 1-2 CKD group (P＜ 0.05).The maximal amplitude, G value and clotting index were significantly higher in non-hemodialysis stage 5 CKD group and stage 4 CKD group than in stage 1-2 CKD group and stage 3 CKD group (P＜ 0.05).Correlation analysis showed that the estimated GFR was negatively related with the plasma fibrinogen and its D-dimer levels, maximal amplitude, G value, clotting index and positively related with the plasma antithrombase Ⅲ level, reaction time and K-time (P＜ 0.05).Multivariate linear regression analysis showed that the clotting index was negatively related with the estimated GFR (P＜ 0.05). Conclusion Anemia, coagulation parameters and TEG contribute to the diagnosis of hypercoagulability in patients with CKD at stage 3-5.