早期宫颈癌患者保留生育功能的可行性与局限性

Feasibility and limitation of preserving fertility in female patients with early cervical cancer

  • 摘要: 目的 探讨早期宫颈癌患者保留生育功能的可行性与局限性。 方法 回顾性分析我院2009年1月-2012年10月宫颈癌行保留生育功能手术13例的临床诊疗情况及结局。 结果 行经阴道宫颈广泛切除及盆腔淋巴结清扫10例,行阴式宫颈次广泛切除2例,行宫颈锥切1例。5例术前行新辅助化疗,方案为卡铂+丝裂霉素+长春新碱(PMV)。术后3例行补充化疗,方案为PMV。1例在术后30个月复发。目前无受孕生产病例。其中1例行辅助生育治疗,促排卵取卵6枚,因内膜薄未行移植术。 结论 早期宫颈癌患者保留生育功能是安全可行的,特别是肿瘤直径< 2 cm。肿瘤大小、阳性淋巴结的存在、淋巴血管间质浸润、深部间质浸润、不良病理类型是复发的重要因素,应在术前仔细评估。

     

    Abstract: Objective To study the feasibility and limitation of preserving fertility in female patients with early cervical cancer. Methods Clinical diagnosis, treatment and outcome of 13 female patients who underwent fertility-preserving surgery for early cervical cancer in our hospital from January 2009 to October 2012 were retrospectively analyzed. Results Of the 13 patients, 10 underwent radical vaginal trachelectomy and pelvic lymphadenectomy, 2 underwent subradical vaginal trachelectomy, and 1 underwent conization. Of the 10 patients who underwent radical vaginal trachelectomy and pelvic lymphadenectomy, 5 received neoadjuvant chemotherapy with PMV and 3 received chemotherapy with PMV after surgery, 1 had recurrence 30 months after surgery. Of the patients who were not pregnant after operation, 1 secreted 6 ova after accessory reproduction treatment. However, the ova were not implanted due to her thin endometrium. Conclusion It is feasible to preserve the fertility of female patients with early cervical cancer with its diameter < 2 cm. The size of cervical cancer, positive lymph nodes, lymphovascular interstitial cells infiltration, deep stromal cells infiltration, and unfavorable histology typing are the important factors for its recurrence and should be carefully assessed before operation.

     

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