Abstract:
Objective To study the feasibility and limitation of preserving fertility in female patients with early cervical cancer.
Methods Clinical diagnosis, treatment and outcome of 13 female patients who underwent fertility-preserving surgery for early cervical cancer in our hospital from January 2009 to October 2012 were retrospectively analyzed.
Results Of the 13 patients, 10 underwent radical vaginal trachelectomy and pelvic lymphadenectomy, 2 underwent subradical vaginal trachelectomy, and 1 underwent conization. Of the 10 patients who underwent radical vaginal trachelectomy and pelvic lymphadenectomy, 5 received neoadjuvant chemotherapy with PMV and 3 received chemotherapy with PMV after surgery, 1 had recurrence 30 months after surgery. Of the patients who were not pregnant after operation, 1 secreted 6 ova after accessory reproduction treatment. However, the ova were not implanted due to her thin endometrium.
Conclusion It is feasible to preserve the fertility of female patients with early cervical cancer with its diameter < 2 cm. The size of cervical cancer, positive lymph nodes, lymphovascular interstitial cells infiltration, deep stromal cells infiltration, and unfavorable histology typing are the important factors for its recurrence and should be carefully assessed before operation.