Abstract: Objective To assess the value of continuous platelet count with platelet function analyzer PL-11 in monitoring platelet function. Methods Platelet function of 26 coronary artery disease (CAD) patients admitted to our hospital in 2012 for anticoagulant therapy with clopidogrel and 45 healthy volunteers was detected by light transmittance aggregometry (LTA) and continuous platelet count with platelet function analyzer PL-11, respectively. The correlation and the different results in the two methods were analyzed. Results The adenosine diphosphate (ADP)-induced maximal aggregation ratio (MAR) detected by LTA and continuous platelet count with PL-11 was well-correlated in CAD patients and healthy volunteers (r=0.766, P＜ 0.000 1). The MAR detected by LTA was higher than that detected by continuous platelet count with PL-11 in CAD patients and healthy volunteers. The mean platelet volume (MPV) was consistent with the MAR in each sample measured by continuous platelet count with PL-11 at different time points. Conclusion The platelet function detected by continuous platelet count with PL-11 and LTA is similar, which can provide reference for their application in clinical practice and laboratory tests. Platelet-rich and whole blood samples may be the reason for the different results of the two methods.