Abstract: Objective To study the effect of continuous blood purification (CBP) at bedside in severe stroke patients with acute kidney injury. Methods The clinical data about 15 severe stroke patients with acute kidney injury admitted to our hospital from January 2006 to August 2011 were retrospectively analyzed. Results All the patients except one who died of thalamus bleeding recovered. The serum levels of creatinine, blood urea nitrogen, potassium, sodium, intracranial pressure, IL-lβ, IL-6, 24 h urinary volume, and Glasgow coma score were significantly higher after CBP treatment than before CBP treatment (230.67±42.34 μmol/L vs 75.47±22.54 μmol/L, 18.74±4.17 mmol/L vs 5.35±0.66 mmol/L, 6.26±0.38 mmol/L vs 4.16±0.44 mmol/L, 158.07±5.16 mmol/L vs 141.60±3.22 mmol/L, 22.73±2.19 mmHg vs 18.40±1.55 mmHg(1 mmHg=0.133 kPa), 0.95±0.07 ng/ml vs 0.42±0.09 ng/ml, 259.13±24.39 pg/ml vs 216.53±17.61 pg/ml, 506±95 ml vs 1 449.33±244.20 ml, 8.20±1.61 vs 10.33±1.91, P＜ 0.01). Head CT scanning revealed no enlarged hematoma. Conclusion CBP at bedside can clear the cytokines, improve the renal function and reduce the intracranial pressure in severe stroke patients with acute kidney injury.