飞行人员代谢综合征患者PGC-1α基因Gly482Ser位点多态性研究

孙燕; 刘红巾; 蔡庆; 徐先荣

doi:10.3969/j.issn.2095-5227.2013.09.004

飞行人员代谢综合征患者PGC-1α基因Gly482Ser位点多态性研究

Correlation between Gly482Ser polymorphism of PGC-1αgene and metabolic syndrome in pilots

摘要

摘要: 目的研究过氧化物酶体增殖物激活受体-γ协同刺激因子-1α(peroxisome proliferators-activated receptor-γcoactivator-1α，PGC-1α)基因Gly482Ser位点多态性与飞行人员代谢综合征(metabolic syndrome，MS)的相关性。方法采用聚合酶链反应-限制性片段长度多态性技术检测42名MS飞行人员和42名健康对照飞行人员PGC-1α基因Gly482Ser位点的多态性。结果飞行人员MS组PGC-lα基因Gly482Ser位点GG、GA及AA基因型构成与对照组存在统计学差异(P＜0.05)(在MS组为28.6%、45.2%和26.2%，而在对照组为52.4%、38.1%和9.5%)，且MS组A等位基因频率明显高于对照组(P＜0.01)(在MS组为48.8%，在对照组为28.6%)。结论 PGC-1α基因Gly482Ser位点多态性可能与飞行人员MS相关，A等位基因可能为一个易感基因。

Abstract: Objective To study the correlation between Gly482Ser polymorphism of PGC-1αgene and metabolic syndrome(MS)in pilots. Methods Gly482Ser polymorphism of PGC-1αgene was detected by PCR in 42 MS pilots and 42 health controls. Results The GG, GA and AA genotypes of Gly482Ser in PGC-1αgene accounted for 28.6%, 45.2%, 26.2% in MS pilots and 52.4%, 38.1%, 9.5% in healthy controls (P＜ 0.05).The frequency of A allele was significantly higher in MS pilots than in healthy controls (48.8% vs 28.6%, P＜ 0.01). Conclusion The polymorphism of Gly482Ser in PGC-1αgene is correlated with MS in pilots.The A allele may be a susceptible gene.

HTML全文

参考文献(0)

施引文献

资源附件(0)