Abstract: Objective To analyze the risk factors for massive hemorrhage in bronchoscopy. Methods One hundred and thirteen patients who underwent bronchoscopy in our hospital from December 2011 to December 2012 were divided into hemorrhage group(blood loss>100 ml) and control group(blood loss<100 ml). Blood loss>300 ml was considered as massive hemorrhage. Their clinical indicators, biopsy findings, and pathological diagnosis were recorded. Results The age and positive rate of hepatitis B or C virus infection were significantly different between the two groups(P<0.05); while no significant difference found in the other indications(P>0.05). Aspergillus infection and hemangioma were the most significant risk factors for massive hemorrhage when the blood loss was>300 ml. Conclusion Hemorrhage should be seriously considered in biopsy of non-malignant tumor patients especially with Aspergillus infection and hemangioma. Strict control of biopsy indications for bronchoscopy can reduce the occurrence of massive hemorrhage.