克拉屈滨治疗复发毛细胞白血病1例并文献复习

Treatment of relapsed hairy cell leukemia with cladribine: A case report and review of literature

摘要: 目的通过1例经克拉屈滨治疗的复发毛细胞白血病的病例分析,进一步了解毛细胞白血病的治疗策略和方法。方法观察2012年4月我院收治的1例经克拉屈滨治疗的毛细胞白血病复发患者的治疗过程,分析毛细胞白血病的临床特点、治疗方法、治疗效果及不良反应,并复习有关文献。结果此例患者经1个疗程克拉屈滨治疗,3个月后达到部分缓解,随访5个月持续部分缓解。结论克拉屈滨是治疗毛细胞白血病的有效方法,不良反应小,耐受性好,适合在中国毛细胞白血病患者中应用。

Abstract: Objective To study the treatment strategies and methods of hairy cell leukemia(HCL) by analyzing 1 case of relapsed HCL after treated with cladribine. Methods The clinical features, treatment methods and their effect, and adverse reactions of 1 case of relapsed HCL admitted to our hospital in April 2012 and treated with cladribine were analyzed with the related literature reviewed. Results The symptoms of the patient were partially alleviated 3 months after treated with cladribine. The patient was followed up for 5 months during which the symptoms were continuously and partially alleviated. Conclusion Cladribine is effective for HCL with few adverse reactions and good tolerance, and can thus be used in treatment of Chinese HCL patients.