Abstract: Objective To improve the diagnosis and treatment of duodenal neuroendocrine tumor by studying its clinical manifestations, endoscopic features, biopsy findings and therapy. Methods Clinical data about 13 patients with duodenal neuroendocrine tumor admitted to our hospital from September 2009 to May 2013 were retrospectively analyzed. Results No specifc clinical manifestation of neuroendocrine tumor was observed in the patients included in this study. Neuroendocrine tumor is usually located in duodenum and solitary. The tumor was hemispherical in shape with polypoid or discoid mucosal bulge, and its surface was congestive, erosive or ulcerative under endoscope. The tumor was tenacious or hard and could be pushed. The tumor was diffcult to locate when its muscularis was involved. Of the 13 patients included in this study, 4 underwent endoscopic resection, 2 surgical resection, 5 duodenopancreatectomy, 2 common bile duct stenting in endoscopic retrograde cholangio-pancreatography (ERCP) (1 died and 1 lost follow-up 2 months after ERCP). Eleven patients were followed up for 24.1 months (mean 6 -43 months) during which no recurrence and death occurred. Conclusion The clinical manifestations of duodenal euroendocrine tumor are not specifc. Endoscopy, pathologic and immunohisotochemical test are the important methods for its early diagnosis and endoscopic or surgical excision is the surgical procedure for its treatment.