Abstract: Objective To study the clinical features of non-functional pancreatic neuroendocrine tumor and its surgical treatment. Methods Clinical data about 79 patients with nonfunctional pancreatic neuroendocrine tumor admitted to our hospital from January 2003 to November 2012 and the infuencing factors for its prognosis were retrospectively analyzed. Results The patients had no typical clinical manifestations. The tumor was located in pancreatic head of 50 cases and in pancreatic body and tail of 29 cases. The tumor was classifed as stages Ⅰ, Ⅱ, Ⅲ and Ⅳ in 41, 20, 10 and 8 patients, respectively, according to the TNM classifcation. Of the 79 patients, 22 underwent distal pancreatectomy (including splenectomy), 19 pancreaticoduodenectomy, 24 enucleation, and 14 palliative surgery. Multivariate analysis showed that the prognosis of the tumor was related with its TNM staging (P＜ 0.01). Conclusion Radical resection of nonfunctional pancreatic neuroendocrine tumor can significantly improve its outcome. TNM staging is an independent factor for the prognosis of such patients.