Abstract: Objective To study the feasibility, safety and manipuniting points of combined guglielmi detachable coils (GDC) and microcoils in embolization of splenic artery aneurysm (SAA). Methods Clinical data about 8 SAA patients who underwent embolization with combined GDC and microcoils in our hospital from January 2012 to March 2013 were retrospectively analyzed. SAA was located at the origin of splenic artery in 2 patients, at the middle segment of splenic artery in 3 patients, and at the hilus lienis in 3 patients. The average diameter of SAA was 24±3.4 mm (20 mm-28 mm). Results The embolization was successfully achieved in all the patients, during which 33 GDCs and 58 microcoils were used without embolization-related complications occurred. The patients were followed up for an average period of 11±4.5 months (5-18 months) during which no blood fow and splenic infarction were observed. Conclusion Combined GDC and microcoils is a safe and feasible procedure for the embolization of SAA. However, its long-term effect needs to be further observed.