Abstract: Objective To study the effect of ultrasound-guided percutaneous catheter drainage on liver abscess. Methods Clinical data (treatment outcome and complication) about 110 patients with liver abscess (156 lesions) who underwent ultrasound-guided percutaneous catheter drainage in our department from January 2010 to December 2012 were retrospectively analyzed. Results Among the 110 patients who underwent ultrasound- guided percutaneous catheter drainage (with a success rate of 100%), the clinical symptoms and signs and liver abscess disappeared, the white blood cells and neutrophils became normal in 86, with a curative rate of 78.2% (86/110)and a complication rate of 4.55% (5/110). Conclusion Ultrasound-guided percutaneous catheter drainage is a safe treatment modality for liver abscess with minimal invasiveness, low complication and recurrence rate, and is thus worthy of wide application in clinical practice.